Mercury sulfide (HgS) nanoparticles embedded in different matrices were synthesized. In the reaction, Mercury nitrate was used as Mercury source; thioacetamide was employed as chalcogenide source. This method has been used to achieve good control over composition and morphology of the products.and the influence of matrices on the dispersion of HgS products was briefly discussed. X-ray powder diffraction (XRD), Transmission electron microscopy (TEM) and scanning electron microscope (SEM) were used to characterize the size and morphology of obtained HgS nanoparticles. The results revealed uniform crystallite aggregates for HgS nanoparticles, with a narrow size distribution.