Four molecularly imprinted polymers (MIPs) of cyproheptadine hydrochloride (CPH) selective senses were prepared based on ion-pair formation using cyproheptadine hydrochloride as a template. Molecularly Imprinted Polymer (MIP) was prepared by using 2-Hydroxyethylmethacrylate (HEMA) as monomer, N, N-Ethylenebismethacrylamide (EBMAA) as cross linker, and benzoyl peroxide as initiator. NIPs prepared by using the same composition of MIPs except the template (CPH). The sensors were prepared using different plasticizers, Di-octyladipate (DOA), Diisobutylbutylmaleate (DIBM), 2-Nitrophenylpentadecylether (NPPE) and 3-Trimethyltrimellitata (TMTM). The potentiometric response of the sensors to cyproheptadine hydrochloride was tested and the selectivity coefficients of inorganic ions, sugars, amino acids, and drugs were studied. The best electrodes obtained were constructed with plasticized DOA and TMTM which have a linear response range from (1 × 10-1 1 × 10-4 and 1 × 10-1 5 × 10-4 M) with slope of 55.4 and 58.8 mV/decade, respectively. The electrodes were used for a period of 35 and 41 days and were tested with good results in synthetic and pharmaceutical CPH samples.