Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Enantioselective synthesis of (S)-1-Boc-3-hydroxypiperidine using enzymes and whole cell biocatalysts
Author(s): Madhuresh K. Sethi, Sanjay Mahajan, Irfan Ahmad Ahanger, Rusha Guha, Rohit Shukla, Mujahid Sufi Ahmed, Bhairaiah Mara, Upendranath Veera and Purbita ChakrabortyPreparation of (S)-1-Boc-3-hydroxypiperidine is an important stereoselective step in the synthesis of many anticancer drugs like tyrosine kinase inhibitors. Our study involved the synthesis of (S)-1-Boc-3-hydroxypiperidineusing Baker`s yeast, ketoreductase enzyme and microbial cells. The novel approach using Baker`s yeast yielded a costeffective, environment-friendly and enantioselective process. The ketoreductase enzyme provided a high chiral selectivity. The time course of the reaction and percent enzyme used was significantly reduced. Synthesis of (S)-1- Boc-3-hydroxypiperidine was also studied using microbial cells. The investigational studies done in this article will surely aid in improving the existing processes in many aspects as discussed above.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 25868
Der Pharma Chemica received 25868 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
DOWNLOADS
