Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Environmentally benign synthetic approach and antimicrobial activity of Co(II) complexes of quinazolin-4(3H)-one derived bidentate schiff bases

Author(s): K. P. Srivastava, Sunil Kumar Singh and Bir Prakash Mishra

A rapid, efficient, clean and environmentally benign exclusive synthesis of Schiff bases as new ligands and their complexes with Co(II) have been developed using condensation of 3-phenyl-2-propyl-quinazolin-4(3H)-onewith semicarbazide (ppqs, L) and thiosemicarbazide (ppqt, L’) efficiently using alkali catalyst with excellent yields under microwave irradiation. This method provides several advantages such as environmental friendliness, simple workup procedure, short reaction times, non-hazardous and excellent yield of products.The results are compared with conventional methods for their yield and reaction time. The Schiff base ligands and the complexes were characterized by micro-analytical, conductometric, magnetic and spectroscopic studies.All the Schiff bases were bidentate (NO donor) ligands. All complexes were found to be six co-ordinate and ML2[1:2 (metal: ligand) ratio] type. The complexes are coloured and stable in air.

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