GET THE APP

Evaluation of anti inflammatory activity of synthetic 7-flavanol derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Evaluation of anti inflammatory activity of synthetic 7-flavanol derivatives

Author(s): M. Karpakavalli, T. Sivakumar, E. P. Kumar and G. Nagaraja Perumal

The inflammation is serious health problem in all industrialized countries due to carcinogens, environmental chemicals, irritant substances and microorganism. The several literatures have been reported that the limited synthetic drug information’s are available from developing countries. The modern day synthetic anti inflammatory drugs possess some adverse effects such as ulcer, prevent the coagulation, nephrotoxicity and hematopoietic changes. The several herbal formulations derived from Ayurveda and its additional systems of medicine, either not yet to be scientifically validated or scientifically validated; that they have flavonoids exhibited pharmacological action against inflammation. The present study was undertaken to investigate anti-inflammatory activity of synthesized flavonoids and its derivatives compound1. As per the literature survey, We have synthesized flavonoids and its derivatives such as 3’4’-dinitro, 7-flavanol, 6, 4’-dinitro, 7-flavanol, 6-dinitro 7-flavanol, 6, 3’4’-trinitro, 7- flavanol, 6-acetyl, 4’-nitro, 7- flavanol, 6-acetyl, 4’-nitro, 7- flavanol and 6-acetyl, 3’4’-dinitro 7-flavanol.The carrageenan induced paw oedema methods in rats were used to comparatively evaluate the anti-inflammatory activity of selected synthesized flavonoids and its derivatives. The one dose level 300mg/kg was prepared by using synthesized flavonoids and its derivatives. The results revealed that the all synthesized flavonoids and its derivatives have shown anti inflammatory activity (*P<0.05, **P<0.01 and ***P<0.001) when compared to control and positive control group. The 3’4’-dinitro, 7-flavanol have expressed (**P<0.05) mild reduction in paw volume when compared to each other groups but positive control Indomethacin 10 mg/kg have showed (***P<0.001) more anti inflammatory activity. The 6-acetyl, 4’-nitro, 7- flavanol and 6-acetyl, 3’4’-dinitro, 7-flavanol were shown moderate reduction in paw volume when compared each other groups.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry