Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Evaluation of in vivo antimutagenic potential of fruits extracts of Withania coagulans

Author(s): Deepika Mathur and R. C. AgrawaL

Medicinal plants play an important role in development of drugs. The present study is based upon the Anti-mutagenic activity of Withania coagulans, a traditionally known herb. The Antimutagenic activity of Withania coagulans fruit extracts was investigated on cyclophosphamide induced micronucleus formation in mouse bone marrow cells. The results confirmed that a single i.p administration of W. coagulans fruit extract at the dose of 500, 1000 and 1500 mg/kg body weight prior to 24 hours have significantly prevented the micronucleus formation in dose dependent manner in bone marrow cells of mice as compared to cyclophosphamide group.


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