Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Evaluation of Nano-formulated Heteroleptic Metal Complexes as Potential Antifungals against Fusarium oxysporum

Author(s): Gumber K, Sidhu A, Sharma VK

The established antifungal moieties viz. 1,2,4-triazole, dithiocarbamate and phosphorous were brought in a single molecule to give a series of metal complexes of cobalt, copper and iron. The synthesized derivatives were further improvised with an essence of nanotechnology for the better application of the non-soluble molecules to get nano-sized dispersion in water. The formulated target compounds were evaluated for their fungicidal potential against Fusarium oxysporum, by poisoned food technique. The overwhelming results were indicated with compound 5 being the best (EC50 value 4.80 ppm).

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