Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Facile Eco-friendly Synthesis, Characterisation and Evaluation of Antimicrobial Activity of Cu(II) Complexes of Tridentate Ligands

Author(s): K. P. Srivastava , Om Prakash Putul and Nagendra Kumar

A facile, fast, simple, highly efficient, environmentally safe and economical method has been used for the synthesis of the two new biologically active 1,2-dihydroquinazolin-4(3H)-ones (L1 & L2) in single step by treating oaminobenzoylhydrazone (o-ABH) with aromatic aldehydes under normal conditions and other two new hydrazones (L3 & L4) by condensing o-ABH with same aromatic aldehydes with superior yields in polyethylene glycol (PEG) as an alternative solvent. The Cu(II) complexes of synthesed ligands have been prepared in an environmentally benign microwave protocol and characterized by elemental analysis, conductivity measurements, magnetic moment, spectral and thermogravimetric analysis. The antimicrobial activity of the free ligands and their Cu(II) complexes clearly indicates that the ligands have both an antibacterial and antifungal potency against the organisms tested. In most cases, the complexes were found to be more active than the free ligands, but in some cases, an equal activity was displayed.


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