Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Formation and interpretation of new spiro thiadiazines

Author(s): Vijay V. Dabholkar, Prem Naik, Abhishek Karekar and Navnath Shinde

Equimolar mixture of substituted triazole (1) and substituted aromatic aldehyde were refluxed in presence of alcoholic KOH to yield 4- substituted-banzylidene-amino-5-substituted-4H-1,2,4-triazole-3-thiol (2), which cyclized to form 2H,3H,4H,2-Carbethoxy, 3-substituted, Phenyl,5-substituted-[1,2,4]-triazole [3,4-b] [1,3,4] thiadiazine (3) using ethyl chloro acetate and K2CO3. Compound (3) was undergoes bromination in the presence of iodine which is act as catalyst to form Bromo compound (4). Compound (4) was further converted into Imino spiro Thiadiazines (6), Hydrazino spiro Thiadiazines (8) and spiro Triazolo-thiadiazines (9) by reacting with Thiosemicarbazones (5), Thiocarbohydrazones (7) and Triazoles (1) respectively. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR and mass spectroscopic analysis.

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