Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Fused pyrimidines: The heterocycle of diverse biological and pharmacological significance

Author(s): Vachala S. Dinakaran, Bhargavi Bomma and Keloth K. Srinivasan

Fusion of pyrimidine moiety with different heterocycle scaffolds gives rise to a new class of hybrid heterocycles possessing improved activity. Heterocycles containing sulphur and nitrogen atoms in the core structure, shows number of pharmacologically and biologically active compounds. So, various fused pyrimidines like purines, pteridines, quinazolines, pyridopyrimidines, triazolopyrimidines, pyrazolopyrimidines, pyrimidoazepines, furopyrimidines and pyrrolopyrimidines were studied in the past decade and were found to possess remarkable pharmacological properties. The present review provides a broad view of the biological and medicinal properties expressed by compounds having fused Pyrimidine nucleus.


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