Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Glycerol-promoted catalyst-free one-pot three component synthesis of 1H-pyrazolo[1,2-b]phthalazinediones

Author(s): Abhijeet Mulik, Madhukar Deshmukh, Dattatraya Chandam, Prasad Patil, Suryabala Jagdale, Dayanand Patil and Sandeep Sankpal

Glycerol-promoted catalyst-free one-pot three component synthesis of 1H-pyrazolo[1,2-b]phthalazinediones has been achieved. Use of greener solvent glycerol, catalyst-free reaction condition, high yields, one pot reaction and simple product isolation method without use of column chromatography are the noteworthy aspects of the synthetic route. Mechanistic route of the reaction proves the promoting nature of the glycerol. Indeed, we accentuated the direct utilization of glycerol as solvent to research community which is indispensable in economical and environmental viewpoint.


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