Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Green condensation reaction of aromatic aldehydes with rhodanine catalyzed by alum under microwave irradiation

Author(s): T. Swathi and Medidi Srinivas

An efficient one pot alum catalyzed, microwave enhanced, clean process for the synthesis of 5-arylidenerhodanines by the Knoevenagel condensation of aromatic aldehydes with rhodanine in aqueous media is described. Only 15 mole % of alum is enough in this protocol to achieve optimal yields and this protocol is fairly general and applicable to aromatic aldehydes. The use of alum, water and MW has promising reaction response, such as short reaction time, excellent product yields, and simple work-up of the products makes the reaction convenient, more economic, and environmentally benign.

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