Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Green synthesis of biginelli products of meldrum acid

Author(s): Vijay V. Dabholkar, Mustaqeem Mohammed A., Navnath B. Shinde, Omprakash G. Yadav

A simple and efficient method has been devised for the synthesis of 3,3-dimethyl-7H,8H,10H-8,10-diaza-2,4-dioxa- 5,9-dioxo-7-(substituted) phenylbicyclo [4.4.0] dec-1(6)-ene (5) and 3,3-dimethyl-7H,8H,10H-8,10-diaza-2,4-dioxa- 5-oxo-9-thioxo-7-(substituted) phenylbicyclo [4.4.0] dec-1(6)-ene (6), by a one-pot three component cyclocondensation reaction of 1,3 dicarbonyl compound (Meldrum), aromatic aldehyde, and urea/thiourea using catalytic amount of fresh lemon juice in refluxing ethanol. Representative samples were screened for their antimicrobial activities against gram-negative bacteria and gram-positive bacteria using disc diffusion method. The structures of the products were confirmed by IR, 1H, 13C NMR and elemental analysis.


ankara escort
mobile bitcoin casino
Casumo no deposit bonus bitcoin nedir?