Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Healing Potency of Citrus, Hesperetin and Naringenin Loaded with Silicate Nanoparticles on Neurotoxicity Induced by Acrylamide Toxic Dose

Author(s): Maha Z. Rizk, Abo-elmatty D.M, Hanan F. Aly, Howaida I. Abd-Alla, Samy M. Saleh, Eman A.Younis

The current research demonstrated the effect of silica loaded nanoparticles (citrus, naringenin and hesperetin) on acrylamide (ACR) intoxicated rats, through measuring specific selected biomarkers on brain. Brain neurotransmitters noradrenaline (NA), adrenaline (A), dopamine (DA) and serotonine (5-HT), acetylcholine esterase (ACHE) andcaspase-3 enzyme activity and DNA degradation (Comet) were evaluated. ATPase enzyme activity and total protein content were also evaluated. Besides, the presented data showed significant deterioration in the all selected biomarkers investigation in aclylamide-intoxicated rats. It showed significant reduction in brain neurotransmitters (NAADA and 5-HT), ATPase enzyme activity and total protein content while significant elevation in AchE and Caspase-3 enzyme activity and DNA damage. Treatment of intoxicated rats with the three silica loaded nanoparticles indicated amelioration with different percentage of improvement in the all measured biomarkers as well as in rat’s brain architecture. Thus it could be concluded that, the using of natural product nanoparticles can up-regulate brain neurotransmitters, suppressing DNA damage, diminished brain damage that leads to delay disease development and/or its complication


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