Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Hepatosuppression Study by Tinospora Cordifolia

Author(s): Shirish S. Pingale

The aim of the present work is to evaluate the effect of Tinospora cordifolia against hepatosuppression induced by carbon tetrachloride (CCl4). The evaluation markers used were serum marker enzymes viz. GOT, GPT, Alkaline phosphate, glucose, bilirubin, Triglycerides, γGT, cholesterol, DNA, RNA and total protein. These biochemical parameters were significantly changed by the single dose of CCl4. The treatment of Tinospora cordifolia significantly recovers all the serum and liver parameters like normal levels. However, silymarin was used as a reference standard for this study. The findings indicate that the hepatoprotective action of Tinospora cordifolia against hepatosuppression possibly involves CCl4 bioactivation through selective inhibitors of reactive oxygen species like antioxidants brought about significant inhibition of TBARS suggesting possible involvement of O2 –, HO2, HO2 –, H2O2 and OH. Light and electron microscope photographs also support the same. Hence Tinospora cordifolia indicating protection in liver may prove promising effect against liver disorders. Thus it may act even in humans as a potent liver tonic


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