Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Highly efficient and practical synthesis of 2-amino chromene derivatives using ionic base

Author(s): Kamlesh M. Khokhani, Vijay R. Ram, Girin A. Baxi and Praful K. Patel

The treatment of substituted benzaldehydes with malenonitrial and orcinol in presence of using ionic base anhydrous potassium carbonate and ethanol as solvent leads to give 2-Amino-3-Cyano Chromene Derivatives 3a 1- 10 and 2-Amino-3-Carboxylate Chromene Derivatives 3b 1-10 obtain by using Ethyl cyanoacetate in place of malenonitrial. All the synthesized cromene derivatives have purity check by TLC. The structures of the compounds were established by elemental analyses and spectral data. All the products were also screened in vitro for their antimicrobial and antifungal activity.


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