The effects of Cyperus esculentus (tiger nut) oil on lipoprotein composition, cholesterol and triglyceride levels and their histological changes were investigated in the brain, liver, kidney and heart of rats. Cyperus esculentus tuber oil was extracted from the tuber using a soxhlet extractor. Twenty, 3 weeks-old albino rats (Rattus norvegicus) with an initial average weight of 51.67±5.29g were grouped into two groups of ten (10) animals each. The first group was fed with soybean oil-based (control) diet; the second group on esculentus tuber oil meal-based diet for six (6) weeks. Histological examination of the selected tissues ((brain, liver, heart and kidney) showed no significant alteration in animals fed both the soybean oil and Tiger nut tuber oil fed animals. Generally, there was also no significant difference (p>0.05) in the serum lipid profile like concentration of Triglycerides, High Density Lipoprotein and Low Density Lipoprotein - cholesterol in rats fed on soybean based oil as compared to that of Tiger nut oil. However there was a significant decrease (p < 0.05) in the Total cholesterol of serum of rats fed with Tiger nut tuber oil-based meal. It was concluded that feeding cyperus esculentus tuber oil meal to rats might be safe on the lipid profile of rats.