Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Hypoglycemic Effect of Mucilage and Methanol Extract of Aegle marmelos (L.) Correa fruits in Stereptozotocin indused Diabetic Rats

Author(s): Nabaweya A Ibrahim, Magdy MD Mohamed, Hanan F Aly, Sanaa A Ali, Abd Al-Hady D

Purpose: The present study aims to evaluate the mucilage and methanol extract of Aegle marmelos (L.) Correa fruit as antidiabetic agents in STZ -induced diabetic rats. Methods: Mucilage of Aegle marmelos (L.) Correa fruit was isolated to yield (15% w/w) and analyzed by using GLC technique revealed the presence of glucose as a major sugar (36.61%), in addition to galactose, arabinose, xylose, mannitol, rhaminose and galacturonic acid. the mucilage and methanol extract of fruit investigated for their possible hepatoprotective effects against liver disorders induced by reactive oxygen species associated with diabetic complications in diabetic rat. The investigated parameters included blood glucose, insulin (to investigate diabetic condition), total cholesterol, triglycerides, total lipid content as indices of liver steatosis, Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), total protein content and total albumin as markers of liver functions, as well as hepatic Nitric Oxide (NO) Andmalondialdehyde (MDA) (marker of lipid peroxidation) in addition to, hepatic gluconeogenic phosphoenol pyruvate carboxy kinase (PECK), Glycolytic enzymes lactate Dehydrogenase (LDH), Pyruvate Kinase (PK) and Hexokinase (HK). Also histopathological studies were investigated. Results: Significant beneficial glycemic control, scavenging free radical, normalized liver function, inhibited lipid synthesis associated with diabetic complication. Conclusion: Mucilage and extract of Aegle marmelos (L.) Correa fruit have principle role in treatment and amelioration of liver damage associated with diabetic status at the biochemical and cellular levels. Further clinical studies must be done in trial to investigate there efficacy in human as new candidate drug.


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