Current antidiabetic drugs are not adequate to manage progression of diabetes. Since natural products have been a good source of drugs, it is necessary to find out new molecules with natural origin for antidiabetic drug development. Tinospora cordifolia has proven efficacy in diabetes. In silico analysis in this work revealed that components of Tinospora cordifolia have good affinity for multiple diabetic targets which may account for its antidiabetic efficacy. Further in silico analysis revealed that aglycone of syringin can be the most appropriate hit molecule which can be optimized for antidiabetic drug development.