Studies on antimycotic potentials of toothpastes on human oral yeast pathogens have been sparse, especially in developing countries, in spite of the increasing reports on problems with inadequate oral hygiene. Using a modification of agar well-diffusion method, in vitro antimycotic potentials of 10 most preferred Nigerian toothpastes and tooth-gels on 86 oral Candida species, C. albicans 43 (50.0%), C. glabrata 5 (5.8%), C. pseudotropicalis 10 (11.6%) and C. tropicalis 28 (32.6%) indicated overall low (20.0%) to high (100%) susceptibility rates among the Candida species. Varied susceptibility rates of 18.6-100%, 20.0-100%, 30.0-100% and 60.7-96.4% were exhibited by the oral C. albicans, C. glabrata, C. pseudotropicalis and C. tropicalis respectively towards the test toothpastes and tooth-gels, although their susceptibility patterns were not species-specific. Minimal overall in vitro inhibitory activities were however, displayed by some strains towards Close Up Red / Dabur Herbal Gel (20.0%), Macleans (18.6-30.0%) and MyMy (23.3%). In conclusion, high in vitro inhibitory potentials of some commonly available toothpastes and tooth-gels in Nigeria on oral Candida strains and can therefore, serve as active teeth-cleansing agents in oral hygiene.