Free radicals are formed through ionizing reactions that are then capable of destroying normal tissues during the exposure to radiation. Nanoparticles are gaining interest in the field of radioprotection. Radioprotecting ability of nanoparticle was evaluated in an in vivo model using albino mice. The aim of the present study is the investigation of the ability of silver nanoparticles (AgNPs), gold nanoparticles (AuNPs) and cerium oxide nanoparticles (CeO2NPs) to protect skin tissues of mice against gamma radiation of whole body exposure to 1.2Sv equivalent dose. The administration of nanoparticles protected the skin cell against radiation-induced damages as revealed by histopathologcal examination of section of skin cell. When administered with nanoparticles at 1 hour prior to whole-body radiation exposure, skin cell were found protected from radiation-induced abnormalities in various cells.The present work will address the effectiveness of nanoparticles in radioprotection in animal models during radiation exposure which will encourage the development of innovative and new approaches to radiation protection, using nanotechnology.