Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


In vivo antioxidative stress measurement of a 1, 2, 4- Tri azole derivative in Drosophila melanogaster oregon K flies

Author(s): Padmanabha S. Manjula a , Balladka K. Sarojini a,b* , Channa G. Darshan Raj a and Ganesh Sanjeev c

Anti oxidative efficacy of a 4-amino-3-(4-chlorobenzyl)-1H-1,2,4- triazole-5(4H)-thione ( C ) is evaluated against electron beam irradiation (EBR) and Paraquat (Pq) induced oxidative stress in Drosophila melanogaster - Oregon K male flies. It is evaluated through biochemical estimation of oxidative stress markers like malondi aldehyde (MDA), glutathione (GSH), antioxidant enzymes like superoxide dismutase (SOD) and catalase (CAT) in th e homogenate of the flies. Elevation in the level of MDA and depletion in the level of glutathione was o bserved in homogenate of flies due to stress induced by both i rradiation and Pq. But significant protective effec t is observed with compound treated flies. The triazole derivativ e emerges as promising molecule with significant an tioxidative stress property.

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