Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Influence of Atorvastatin on the pharmacodynamics of Glipizide in normal and diabetic rats

Author(s): A.Mishra, R. Kumari, P. N. Murthy and P. P. Dash

This work reports the evaluation of the influence of atorvastatin on glipizide in normal and diabetic rats. Glipizide produced hypoglycemia activity in a dose dependent manner in normal and diabetic condition. In the presence of atorvastatin, glipizide produced early onset of action and maintained for longer period compared to glipizide group.

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