Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Influence of Dielectric constant on Protonation Equilibria of LMethionine in aqueous solutions of propylene glycol and acetonitrile

Author(s): K. Bhaskara Rao, N.V.V. Simhadri, T. Siva Rao and G. Nageswara Rao

The protonation constants of L-methionine have been studied pH metrically in various concentrations (0.0-60.0% v/v) of propylene glycol- and acetonitrile- water mixtures maintaining an ionic strength of 0.16 mol L-1 at 303.0 K. The protonation constants have been calculated with the computer program MINIQUAD75 and the best fit chemical models are selected based on statistical parameters. Linear variation of step-wise protonation constants (log K) with reciprocal of dielectric constant of the solvent mixture has been attributed to the dominance of the electrostatic forces.

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