Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Influence of Dielectric constant on Protonation Equilibria of LMethionine in aqueous solutions of propylene glycol and acetonitrile

Author(s): K. Bhaskara Rao, N.V.V. Simhadri, T. Siva Rao and G. Nageswara Rao

The protonation constants of L-methionine have been studied pH metrically in various concentrations (0.0-60.0% v/v) of propylene glycol- and acetonitrile- water mixtures maintaining an ionic strength of 0.16 mol L-1 at 303.0 K. The protonation constants have been calculated with the computer program MINIQUAD75 and the best fit chemical models are selected based on statistical parameters. Linear variation of step-wise protonation constants (log K) with reciprocal of dielectric constant of the solvent mixture has been attributed to the dominance of the electrostatic forces.


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