Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Inulin Improves Hepatosteatosis in Humans

Author(s): Mina Wassef Girgiss, Wassef Girgiss Nicola, Dawoud Fakhry Habib, Aly Mohamed Ezz El-Arab4, Nadia A Mohamed, Eman Refaat Youness

Fatty liver is a common clinical finding; it is widely spread in an epidemic form all over the globe. Its finding ushers the presence of other grave abnormalities including; obesity, type 2 diabetes mellitus, cardiovascular diseases beside the ongoing pathology of the liver itself. Hypertriglyceridemia usually accompanies the aforementioned abnormalities. Inulin type prebiotic escapes digestion in the upper part of the gut and reaches the colon, where it enhances the beneficial strains of the microbiota which suppress the pathogenic strains that encourage lipogenesis. Our aim is to study the effect of inulin fructans on patients with hepatic steatosis. Four grams of inulin fructans were given daily for each of the twenty eight obese type 2 diabetic female patients of this study for a period of three weeks. Parameters estimated: Liver Fat Index (LFI), fasting serum insulin level and fasting serum liver transferases (GGT, AST & ALT). Both liver fat index and fasting serum insulin level showed a significant decrease after inulin intake. Again, GGT showed marked numerical drop and AST dropped significantly after inulin ingestion while ALT showed no significant change. In conclusion, inulin fructans seems to be a valuable add on therapy for hepatic steatosis treatment.

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