Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

In-Vitro Alpha-Amylase Inhibitor Activity and Antioxidant Activity of Actinobacteria Isolated from Marine Sediment Samples

Author(s): Elizabeth Mathew, Haimanti Mondal, Priyanka Kharat, Purbasha Saha, KV Bhaskara Rao

Marine environment is a diverse and untapped source of a wide variety of biologically active compounds. Among several organisms, marine actinomycete has been known to be a potential source for novel enzymes. Diabetes mellitus is a long term metabolic disorder characterized by hyperglycaemia. In the present study, marine actinobacteria isolated from the marine sediments of the coastal areas of Kothapattanam, Ongole, Andhra Pradesh, were used to screen for alpha-amylase inhibitor and antioxidant compounds, which are known to manage type 2 diabetes. A total of 20 actinobacteria were isolated from the marine sediments. Among the 20 isolates, an actinobacterial isolate designated VITMA1 showed 58.16% inhibition against alpha amylase enzyme. Further, VITMA1 also exhibited antioxidant activity. It showed 61.82% of DPPH radical scavenging activity, reducing power at 1.933 and a metal chelating activity of 20.33% respectively. The combined effect of antioxidant activity and alpha-amylase enzyme inhibition makes the secondary metabolite obtained from marine actinobacterial isolate, a potent anti-diabetic drug. Based on phenotypic characteristics, VITMA1 was identified upto the genus level as Streptomyces sp.


FIND ARTICLES
SCImago Journal & Country Rank
 
kız uzun zamandır masaj salonunda çalışıyor çok sulanan erkek oluyor ama porno izle bir türlü hiç birine vermiyor Ama sonunda genç paraya sıkışıyor ve bir porno resimleri sikiş için çok para teklif eden genç adama sonunda kabul ediyor ve evlerine giren amatör pornolar maskeli hırsız genç kadının odasındaki çekmecelerde para ararken kadının seksi iç sikiş çamaşırlarına denk geliyor Onları koklayarak yarağı taş gibi oluyor daha sonra genç porno fotoğrafları kadın odaya bir den bire girince hırsızı görüyor ve bağırmaya başlıyor Hırsız hızlıca porno hikayeleri kızın ağzını elleri ile kapatarak tam kızın kalçalarını kucağına alarak sevişiyor
ankara escort
mobile bitcoin casino
Casumo no deposit bonus bitcoin nedir?