This paper describes the effect of methoxy bergenin isolated from the raru’s stem bark ethanol extract (Vatica pauciflora blume) on the total protein, albumin and globulin levels. The 4 × 4 ccompletely randomized design is done by envolving 16 Wistar rats of ± 3 mon age, ± 100 g weight. Group 1 was treated by only feed as a control, and each of the other groups i.e., Group 2, Group 3, and Group 4 by doses of 65 mg/200 g body weight/2 ml, 130 mg/200 g body weight/2 ml and 195 mg/200 g body weight/2 ml respectively, which provided during 21 days. The Wistar rats’ total protein, albumin and globulin level was measured on the 21st day by Folin's phenol method. Data was analized by ANOVA, and showed that administration of methoxy bergenin of the raru stemb bark’s ethanol extract (V. pauciflora blume) effect the total protein, albumin and globulin levels of Wistar rats’ blood significantly.