Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Microwave Assisted One Pot Synthesis of 2, 3-Di-Substituted Quinazolin-4-(3h)-Ones and Their Potential Biological Activity

Author(s): Akhil A. Nagar, Dr. L. G. Rathi, Dr. Naresh Chugh, Vilas J. Pise, Atul Bendale

The 2, 3-di-substituted quinazolin-4-(3H)-ones (III) have been synthesized as a one pot procedure from the reaction of Anthranilic acid (I), acid chlorides and primary amines with the intermediate 4-(3H)-benzoxazinone (II) at different microwave conditions. High yield, less by products, short reaction time (7-10 min), mild conditions and easy work-up are the advantages of this methodology.

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