Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Microwave assisted synthesis and photochemical reactions of 3-(amine dithiocarbamyl) phthalides

Author(s): K. P. Srivastava, Sweta Singh and Harimohan Kumar

An efficient and environmentally benign exclusive method of synthesis of 3-(amine dithiocarbamyl ) phthalides has been developed using reaction of 3-chlorophthalide with amine dithiocarbamate effectively in an aqueous medium with excellent yields under microwave irradiation. The results were compared with conventional methods. All the ecofriendly synthesized 3-(amine dithiocarbamyl) phthalides were characterized by analytical and spectral methods. The photochemical decomposition of 3-(amine dithiocarbamyl) phthalides yielded meso-3, 3’- dihydrobiphthalideas the onlyisolable product. The mechanisms of the green synthesis and photochemical reactions have also been studied.

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