Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Microwave irradiated high-speed and classical synthesis of benzylidene acetyl pyrroles

Author(s): Meghasham N. Narule

A microwave irradiated high-speed and classical synthesis of benzylidene acetyl pyrroles involving Claisen-Schimidt condensation reaction using solid basic alumina under microwave irradiation (MWI) is described. All compounds show antibacterial and antifungal activities when compared with standard drug Norfloxacin and Griseofulvine against Bacterial cultures such as E. coli, Pseudomonus aeruginosa, S. aureus, Proteus vulgaris and fungal cultures Aspergillus niger and Candida albicans. The synthesized compounds are characterized by FTIR, 1H NMR elemental and chemical properties.


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