Dengue virus and Chikungunya virus share a common vector and their co-infection is being increasingly reported. Earlier we have demonstrated efficacy of MBZM-N-IBT against Chikungunya in vitro. Encouraged by this, in the present work we have investigated its potential against non-structural proteins targets of Dengue virus by in silico studies. Molecular docking data has revealed that MBZM-N-IBT has good potential to inhibit NS3 and NS5 proteins. However it has poor affinity for NS1. Considering the critical role of NS3 and NS5 in pathogenesis and progress of Dengue virus, MBZM-N-IBT can be expected to have good inhibition against it.