Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Molecular Iodine Catalyzed Synthesis of 9-Substituted Derivatives of 9-Phenyl-2,9-Diphenyl-5,9-Dihydro-6 H-Pyrimido[4,5-d] [1,3,4]Thiadiazolo[3,2-a] Pyrimidine-6,8(7H)-dione

Author(s): Vijay N Bhosale, Sunil S Choudhare, Gopinath S Khansole, Navanand B Wadwale

A green, most efficient procedure has been developed for the synthesis of 9-substituted derivatives of 9-(4’-phenyl)-2-phenyl-5,9-dihydro-6H-pyrimido[4,5-d][1,3,4]thiadiazolo[3,2-a] pyrimidine-6,8(7H)-dione from a multicomponent one pot three component condensation of 2-amino-5-phenyl 1,3,4-thiadiazole, barbituric acid was refluxed independently in acetonitrile and molecular iodine with different substituted aldehydes. The formed compounds were screened potent Antioxidant activity.

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