Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Montmorillonite K-10: An efficient and reusable cat alyst for the one-pot multi component microwave synthesis of diethyl 1-(4-aryl) -4-phenyl-1 H -pyrrole-2,3- dicarboxylates

Author(s): S. Ahammad Kabeer, N. Maheswara Reddy, G. Mohan, B. Mahesh and C. Suresh Reddy*

An efficient and green one-pot multi component micr owave synthesis of diethyl 1-(4-aryl)-4-phenyl-1H-p yrrole-2,3- dicarboxylates has been accomplished under solvent- free conditions from the reaction of benzaldehyde, diethyl acetylenedicarboxylate and nitroalkane with various amines. The merit of the methodology is that the i nterlamellar structure of the montmorillonite K-10 favoured the reaction in synthesizing the tetra substituted pyrr oles with the environmentally benign reaction conditions by offer ing good product yields


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