Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Novel oxoketene dithioacetal based protocols to the synthesis of a series of 3- amino acids and sulpha drugs embellished analogues of the privileged 1, 4 benzodiazepines for their possible use as CCK A antagonists

Author(s): Sumitra Nain *1 , Swapnil Sharma 1 , Dharma Kishore 2 and Sarvesh Paliwal

Expedient protocols based on the versalility of oxo ketenedithio acetals in synthesis ,has been develop ed to the preparation of the library of many amino acids and sulpha drugs embellished analogues of the privilege d 1,4 benzodiazepines for their possible use as CCK A antagonists .The process to its preparation proce eded with the reaction of 3-oxoketene dithio acetal analogues of 1,4 benzodiazepin-2- one with amino acids and sulp ha drugs followed by treatment of the resulting species with alkali to deliver 3(a-d) ,4(a-b), 5(e-f) and (6 c- d) respectively ,in acceptable yields


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