Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Novel synthesis of 4-amino-2-hydroxymethyl-1-butanol and its purine analogues

Author(s): Vascuri Janardhana Rao, Rama Shankar, Khagga Mukkanti and N. A. Vekariya

Novel and improved synthesis of Famciclovir drug substance through N-(2-amino-4-chloro-6-[[4-hydroxy-3- (hydroxymethyl)butyl]amino]pyrimidin-5-yl)formamide from 4-amino-2-hydroxymethyl-1-butanol and N-(2-Amino- 4,6-dichloro-5-pyrimidinyl)formamide. Further this synthetic method involves the 2-acetoxymethyl-4-azido-1-butyl acetate and 4-azido-2-hydroxymethyl-1-butanol as novel intermediates in the preparation of 4-amino-2- hydroxymethyl-1-butanol.


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