Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

N-Substituted-1,2,3-triazoles: Synthesis, characterization and antimicrobial activity studies

Author(s): Senthil S. and Gopi R

Triazoles display a broad range of biological activities and are found in many potent, biologically active compounds, such as trazodone (antidepressant drug), rizatriptan (antimigrane drug), hexaconazole (antifungal drug) and alprazolam (hyptonic, sedative and tranquilizer drug). So far, modifications of the triazole ring have proven highly effective with improved potency and lesser toxicity.1,2,3-triazole appended bromoquinoline carboxylic acid derivatives were synthesized from Isatin and keto-functionalized triazole derivative. Chemical structures of the synthesized compounds were confirmed by various spectral techniques. All the compounds were subjected to antimicrobial and anti fungal studies showed moderate to good properties.


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