Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


One pot method for green synthesis of 1,5-benzodiazepines

Author(s): Mallinath Langade

Malonic acid has been found to be an efficient catalyst for the synthesis of 2,3-dihydro-1 H -1,5- benzodiazepines from o-phenylenediamine and ketones. This method is simple, cheap, and environmentally-friendly and gives the benzodiazepines in excellent yield.

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