Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


One pot synthesis of dihydropyrimidinones catalyzed by Cyanuric chloride: An improved procedure for the Biginelli reaction

Author(s): Anil Kumar Jogula, Shanmugam Chellapalli and Harish Babu Pendem

We report herein the use of Cyanuric chloride as a new catalyst for the one-pot Biginelli reaction coupling of β-ketoester, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones/thiones.

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