Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Pharmaceutically fine synthesis and their study of antimicrobial activity of metal complexes with some schiff's bases

Author(s): Mahendra Devidas Shelar, Shujat Quadri, Arif Pathan, Suresh Kamble, Mazahar Farooqui, Durrani Ayesha Nuzaat, J. D. Shaikh, Maqdoom Farooqui, Faozia Mansoor Syed

In this newly approached method a novel series of transition metal complexes were synthesized by reactions with various Schiff base compounds such as 2,2.-{ethane-1,2-diylbis [nitrilo (E) methylylidene]} Diphenol, 2,2.-{propane-1,3-diylbis [nitrilo (E) methylylidene]} Diphenol, 2,2.- {1,3-phenylenebis [nitrilo(E) methylylidene]} Diphenol, 6,6'-((1E,1.E)-(propane-1,3-diylbis (azanylylidene)) bis(methanylylidene))bis(2,4-di-tertbutylphenol), 2-[(E)-(pyridin-2-ylimino) methyl] phenol, 2, 4-di-tert-butyl-6-[(E)-(pyridin-2-ylimino) methyl] phenol . Schiff base compounds were treated with transition metal ions of Ni2+, Co+2, Cr+2, Fe+3 and Cd2+. For current work different molar ratios of metals are used. These metal complexes were synthesized under maintained temperature at reflux condition within few hours. Such transition metal complexes of Schiff base compounds were characterized as IR, 1H-NMR, C, H, N and O and their antibacterial activity of metal complexes were studied. Simply these reactions shows bright path to new class of medicinally important compounds.

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