Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Physical Evaluation of Anti-aging and Anti-acne Andaliman (Zanthoxylum acanthopodium DC.) Ethanolic Extract Peel Off Gel Mask

Author(s): Ismanelly Hanum , Lia Laila

This research reports the formulation and physical evaluation of ethanol extract of andaliman fruit in peel off gel mask as anti-aging and anti-acne dosage form. The extraction process of andaliman fruit was conducted by percolation, then the extract was tested for the anti-oxidant activity by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method and anti-bacterial effect by disc diffusion method. The optimum antibacterial concentration was formulated in peel off gel mask using Carbomer and HPMC as the gelling agent. The formula was evaluated for the physical properties included organoleptic, pH, homogeneity, viscosity, spreadability, adhesiveness and irritation test. The andaliman ethanolic extract showed strong anti-oxidant activity with IC50 of 100,76 mcg/ml. The effective concentration of andaliman ethanolic extract as antibacterial was 300 mg/ml with inhibition diameters for Propionibacterium acnes and Staphylococcus aureus were 15.95 ± 0.46 mm and 14.61 ± 0.53 mm, respectively. The evaluation of peel off gel mask showed that both formulae using HPMC and Carbomer had the same color, odor, and homogeneity. The pH and viscosity evaluation showed that HPMC formula had lower pH and viscosity compared to Carbomer formula. Both HPMC and Carbomer formula had no reaction on irritation test. It is concluded that andaliman fruit ethanolic extract can be formulated in peel off gel mask with acceptable physical properties to be used as anti-aging and anti-acne dosage form.

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