Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Physicochemical and biological evaluation of some schiff base by conventional and microwave assisted method

Author(s): Sandip Sen, N. A. Farooqui, Satyajit Dutta, T. S. Easwari, Vikas Gangwar, Kirti Upadhya, Sanjay Verma and Asish Kumar

A series of Schiff base derivatives has been synthesized by reaction between aromatic aldehydes and various aromatic by conventional and microwave assisted method. The structures of the compounds have been confirmed by IR and 1HNMR spectroscopy. The pka value and partion coefficient of the compounds have shown that compounds are acidic and lipophillic in nature. From biological investigation it was found that all the compounds have been shown potent antimicrobial, CNS depressant and analgesic activitie compare to standards.


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