Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Phytochemical composition and anti-inflammatory activities of Brachystegia eurycoma seeds and stem bark

Author(s): Okenwa Uchenna Igwe and Donatus Ebere Okwu

Brachystegia eurycoma seeds and stem barks which are used as food and medicine in South Eastern Nigeria were analyzed for their phytochemical composition and anti-inflammatory activities. Phytochemical investigations showed the presence of bioactive compounds to include alkaloids (0.70-1.74%), flavonoids (3.72-4.99%), tannins (0.37-0.19%), saponins (0.07-1.94%) and phenols (0.03- 0.13%). The anti-inflammatory activities of the extracts at concentrations of 100 and 50 mg/kg body weights were evaluated in carrageenan-induced acute and formalininduced chronic inflammatory models in 36 albino rats. Inhibition of acute inflammation of B. eurycoma seeds were 46.66% and 61.92% while the chronic inflammation gave 32.82% and 49.84%. The stem barks gave 54.27% and 66.34% inhibition of acute inflammation while inhibition of chronic inflammations were 44.82% and 55.45%. These results signify that the extracts from B. eurycoma possess marked anti-inflammatory activities which may be due to the presence of bioactive constituents in them.

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