Brachystegia eurycoma seeds and stem barks which are used as food and medicine in South Eastern Nigeria were analyzed for their phytochemical composition and anti-inflammatory activities. Phytochemical investigations showed the presence of bioactive compounds to include alkaloids (0.70-1.74%), flavonoids (3.72-4.99%), tannins (0.37-0.19%), saponins (0.07-1.94%) and phenols (0.03- 0.13%). The anti-inflammatory activities of the extracts at concentrations of 100 and 50 mg/kg body weights were evaluated in carrageenan-induced acute and formalininduced chronic inflammatory models in 36 albino rats. Inhibition of acute inflammation of B. eurycoma seeds were 46.66% and 61.92% while the chronic inflammation gave 32.82% and 49.84%. The stem barks gave 54.27% and 66.34% inhibition of acute inflammation while inhibition of chronic inflammations were 44.82% and 55.45%. These results signify that the extracts from B. eurycoma possess marked anti-inflammatory activities which may be due to the presence of bioactive constituents in them.