Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


PMA/SiO2: An efficient synthesis of 2-substituted 1,3-benzazoles by green approach

Author(s): V. Sinivas Goud and Monalisa Boruah

A mild, efficient and an eco-friendly method is described to synthesis of 1,3-benzazole by Phosphomolybdic acid supported on silica gel (PMA/SiO2) facilitated reaction of 1,2-phenylenediamine / 2-aminothiophenol with alkyl/aryl aldehydes with excellent yield. A variety of benzazoles derivatives were prepared by using this green methodology in good yields and PMA/SiO2 was found to be an inexpensive and reusable catalyst.

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