Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Potent antimicrobial agents derived from combination of transition metal with sulfamethizole and phthalic anhydride

Author(s): Hitesh R. Patel and Asha D. Patel

In the present study a novel 2-[{4-(N-(5-methyl-1,3,4-thiadiazol-2-yl)sulfamoyl)phenyl}carbamoyl]benzoic acid (MTSPCB) was prepared by reaction of phthalic anhydride with Sulfamethizole. The prepared ligand was characterized by elemental analysis and spectral studies. The transition metal complexes viz. Cu2+, Ni2+ , Co2+ , Mn2+ and Zn2+ of MTSPCB were prepared and characterized by metal-ligand (M:L) ratio, IR, reflectance spectroscopies and magnetic properties. All the prepared metal complexes and ligand were studies as antimicrobial agent. Among all the metal complexes, Zn2+ and Cu2+ metal complexes have shown significant activity.


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