Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry


Preparation, characterization and atomic absorption spectroscopic determination of some metal complexes of glipizide

Author(s): Hassan R. H. Ali*, Gamal A. Saleh, Samiha A. Hussein and Ahmed I. Hassan

Glipizide is a commonly used sulfonylurea oral hypoglycemic drug. The present work reports the preparation and characterization of its metal complexes with cadmium, mercuric, ferric, zinc, cobalt, nickel and calcium. The existence of these complexes has been confirmed by FTIR spectroscopy, which revealed that formation of these complexes was in 2:1 stoichiometry of glipizide and each studied metal, respectively. Close FTIR inspection suggested the co-ordination of nitrogen and carbonyl oxygen atom of –SO2NHCONH- moiety of glipizide with the studied metals. Further, the formed complexes have been analyzed using atomic absorption spectroscopy. The method was successfully applied for the indirect determination of glipizide in its dosage form for the first time.

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