Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Quantitative Estimation of Telmisartan in Marketed Formulation by using Hydrotropic agents

Author(s): Ganesh Prasad Mishra, Rishabh Maheshawari, Hemant M Joshi

An accurate, precise, sensitive and economical procedures for the determination of Telmisartan in tablet dosage form have been developed. In the present investigation, A mixture of 5.0 M urea solutionand1.0M citric acid solution (hydrotropic solubilizing agent) was employed to solubilize, telmisartantablets to carryout spectrophotometric analysis. The result showed that Beer’s law was obeyed in concentration range of 5-50 mg/ml with good linearity (r2>0.99) for both the drugs in both methods. The recoveries were within 99.12 -101.04% for Telmisartan. The optimized methods showed good reproducibility and recovery with standard deviation of < 1.0% and percent relative standard deviation less than 2.0%.


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