Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Quaternized Chitosan Quinoline Derivative with Potential Antibacterial Activity

Author(s): Vishalakshi B, Anush SM, Gangadhar Babaladimath

In this work, a quaternized chitosan derivative has been made by reacting chitosan with 2-hydroxy quinoline-3-carbaldehyde in presence of acetic acid to form a Schiff base intermediate, followed by reaction with sodium borohydride and methyl iodide to obtain the water soluble quaternized product. The heterocylclically modified quaternized compound was characterized by Fourier Transform Infra-Red (FTIR), X-rey Diffraction (XRD), Thermogravimetric Analysis (TGA) and UV-Visible spectroscopy. The antimicrobial activity of the quaternized product was investigated against Gram-positive and Gram-negative bacteria using agar well diffusion method. The results showed that the modified compound showed good inhibitory action attributed to the presence of hydrophobic quinoline moiety.


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