Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Quercetin Ameliorates Endothelial Dysfunction and Prevents Elevation of Asymmetrical Dimethylarginine in Experimental Diabetes

Author(s): Jihan Hussein, Zakaria El- Khayat, Yasmin Abdel Latif and Sahar Khateeb

Antioxidants that derived from food have a powerful potential effects on several diseases associated with oxidative stress. The goal of our work was to evaluate the role of quercetin on endothelial dysfunction and asymmetrical dimethylarginine (ADMA) levels in experimental diabetes, rats were divided into four groups including control, quercetin, diabetic and treated groups. Diabetic rats were treated with quercetin; blood glucose and plasma insulin were estimated. Liver superoxide dismutase (SOD), reduced glutathione (GSH) and plasma nitric oxide (NO) were measured. ADMA was estimated by reversed phase HPLC. Our results revealed an increase in insulin resistance and ADMA concomitant with a decrease in plasma nitric oxide, liver superoxide dismutase and reduced glutathione activities while treatment with quercetin significantly ameliorated these parameters in treated group compared to diabetic group. Also a negative correlation between ADMA and NO was found accompanied with a positive correlation between ADMA and insulin resistance. The important role of quercetin in attenuating endothelial dysfunction and elevated ADMA levels provides strong evidence that it may be a promising antidiabetic and protective natural product against cardiovascular complications related to diabetes.


FIND ARTICLES
SCImago Journal & Country Rank
kız uzun zamandır masaj salonunda çalışıyor çok sulanan erkek oluyor ama porno izle bir türlü hiç birine vermiyor Ama sonunda genç paraya sıkışıyor ve bir porno resimleri sikiş için çok para teklif eden genç adama sonunda kabul ediyor ve evlerine giren amatör pornolar maskeli hırsız genç kadının odasındaki çekmecelerde para ararken kadının seksi iç sikiş çamaşırlarına denk geliyor Onları koklayarak yarağı taş gibi oluyor daha sonra genç porno fotoğrafları kadın odaya bir den bire girince hırsızı görüyor ve bağırmaya başlıyor Hırsız hızlıca porno hikayeleri kızın ağzını elleri ile kapatarak tam kızın kalçalarını kucağına alarak sevişiyor
ankara escort
mobile bitcoin casino
Casumo no deposit bonus bitcoin nedir?