Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Regioselective synthesis of sugar fused dispiropyrrolizidines via intermolecular 1,3-dipolar cycloaddition reaction

Author(s): Sirisha Nallamala and Raghavachary Raghunathan

An expedient method for the synthesis of glyco dispiropyrrolizidines is reported through 1,3-dipolar cycloaddition reaction (1,3 DC reaction). The novel glycosyl dipolarophile derived from D-glucose underwent neat [3+2] cycloaddition reaction with the azomethine ylides generated from di/tri ketones and proline to give the corresponding glycosidic heterocycles in good yields.


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