Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry and Computational Chemistry

Abstract

Reveal antifungal activities of essential oils from Lavandula dentata L. a way of valuing the arganeraie

Author(s): Ali Asdadi, Aicha Hamdouch, Said Gharby, Radouane Moutaj, Bouchra Chebli and Lalla Mina Idrissi hassani

The Argane tree localized mostly in the southwest of Morocco, under its shade, original micro-ecosystem of medicinal and aromatic plants and characterized by an extraordinary endemism whose forms part Lavandula dentata L. To preserve the Argane forest, and develop its surrounding ecosystem, our study aims to valorising the essential oils of the Lavandula dentata L, studying the antifungal activities of these essential oils on Candida species clinically isolated from patients with candidiasis nosocomial, comparing it to that of two conventional antifungal drugs: Amphotericin B and Fluconasole. Indeed Emerging nosocomial candidiasis is a major issue for health care professionals by their poor prognosis and resistance to conventional antifungal agents used in the current practice of hospitals. The minimum inhibitory concentration was determined by the method of macro dilution broth in agreement with the guidelines of NCCLS M38P for yeasts. The results are very convincing indeed the antifungal activity of Essential oil is important with an minimum inhibitory concentration of 0.26 mg/ml against all Candida non-albicans found resistant to fluconazole, and with an minimum inhibitory concentration of 0,53mg/ml against Candida albicans studied.


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